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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>NSC59984
NSC59984
  • NSC59984

NSC59984 NEW

Price $38 $65 $137
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: NSC59984 CAS No.: 803647-40-7
Purity: 99.59% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameNSC59984
DescriptionNSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
Cell ResearchCells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference)
In vitroNSC59984 selectively reactivates the p53 pathway and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. It also promotes cell death in various cancer cell lines with different p53 mutations, showing minimal genotoxicity in normal cells. [1]
In vivoIn nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationEthanol : 49 mg/mL (184.72 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 55 mg/mL (207.34 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.54 mM), Sonication is recommended.
Keywordsp53 | NSC-59984 | NSC59984 | NSC 59984 | MDM-2/p53 | Inhibitor | inhibit
Inhibitors Related10-Hydroxydecanoic Acid | Flubendazole | Diuron | Gallium maltolate | Rotenone | D-(-)-3-Phosphoglyceric acid disodium | Triglycidyl isocyanurate | Indole-3-carbinol | Methyl methanesulfonate | (E/Z)-10-Hydroxy-2-decenoic acid | Magnolol | Diethanolamine hydrochloride
Related Compound LibrariesAnti-Lung Cancer Compound Library | Glycometabolism Compound Library | Target-Focused Phenotypic Screening Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Ubiquitination Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Cancer Metabolism Compound Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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