Numidargistat NEW
| Price | $3120 | $3880 | $5000 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-19 |
Product Details
| Product Name: Numidargistat | CAS No.: 2095732-06-0 |
| Supply Ability: 10g | Release date: 2026/05/19 |
Product Introduction
Bioactivity
| Name | Numidargistat |
| Description | CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2). |
| In vitro | CB-1158 is not directly cytotoxic to murine cancer cell lines [1]. CB-1158 inhibits native arginase 1 (Arg1) in human granulocyte, erythrocyte, and hepatocyte lysate (IC50s: 178 nM, 116 nM, and 158 nM) and blocks Arg1 in cancer patient plasma (IC50, 122 nM). CB-1158 shows no effect on NOS and it also shows potent inhibitory activity against arginase in human HepG2, K562 cell lines, and primary human hepatocytes (IC50s: 32, 139, 210 μM). |
| In vivo | CB-1158 in combination with PD-L1 blockade or gemcitabine inhibits tumor growth in mice bearing CT26 cancer cells. CB-1158 (100 mg/kg, p.o., twice per day) increases the number of tumor-infiltrating cytotoxic cells and decreases myeloid cells in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Numidargistat | INCB-01158 | INCB 01158 | CB1158 | CB 1158 | Arginase 2 | Arginase 1 |
| Inhibitors Related | Piceatannol 3'-O-glucoside | Urea | Guanidine hydrochloride | Numidargistat dihydrochloride | 2-Aminoimidazole | L-Ornithine | L-Valine | BEC hydrochloride | Nor-NOHA monoacetate | L-Norvaline | Nω-Hydroxy-nor-L-Arginine Dihydrochloride | DL-Norvaline |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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CAS:2095732-06-0
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Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $3880.00 |
VIP4Y
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TargetMol Chemicals Inc.
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2026-05-19 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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