OATD-02 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: OATD-02 | CAS No.: 2146132-73-0 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | OATD-02 |
| Description | OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase 1 and Arginase 2 that exhibits slow dissociation kinetics and nanomolar potency across human and murine arginases, effectively reversing arginase-mediated tumor immunosuppression and enabling mechanistic studies in melanoma immunotherapy research. |
| In vitro | In enzymatic assays, OATD-02 inhibited recombinant human ARG1/ARG2 (IC50 20/39 nM) and rodent ARG1 variants. In cellular models, it inhibited human ARG2 in CHO-K1 cells (IC50 171.6 nM) and mouse ARG in bone marrow macrophages (IC50 912.9 nM), while showing a significantly higher IC50 (13 mM) for ARG1 in human primary hepatocytes [1]. |
| In vivo | Oral administration of OATD-02 (10 mg/kg) demonstrates bioavailability of 13% in mice, 30% in rats, and 61% in dogs. A dosage of 5 mg/kg maintained a 4-fold increase in plasma L-arginine levels one week after treatment cessation. In a B16F10 orthotopic melanoma model, treatment with OATD-02 (50 mg/kg, twice daily, p.o.) for 15 days resulted in a Tumor Growth Inhibition (TGI) of 46% [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Piceatannol 3'-O-glucoside | Urea | Guanidine hydrochloride | Numidargistat dihydrochloride | 2-Aminoimidazole | L-Ornithine | L-Valine | BEC hydrochloride | Nor-NOHA monoacetate | L-Norvaline | Nω-Hydroxy-nor-L-Arginine Dihydrochloride | DL-Norvaline |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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