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Postion:Product Catalog >OPC-167832
OPC-167832
  • OPC-167832

OPC-167832 NEW

Price $1170 $1530 $2440
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2026-06-03

Product Details

Product Name: OPC-167832 CAS No.: 1883747-71-4
Supply Ability: 10g Release date: 2026/06/03

Product Introduction

Bioactivity

NameOPC-167832
DescriptionOPC-167832 is a highly potent and orally bioavailable dprE1 inhibitor with an IC?? of 0.258 μM. It exhibits anti-mycobacterial activity against Mycobacterium tuberculosis and can be used in tuberculosis-related research.
In vitroMethods: In vitro drug sensitivity testing of OPC-167832 was performed on Mycobacterium tuberculosis and various standard strains, and its bacteriostatic and bactericidal activities against intracellular Mycobacterium tuberculosis were determined. Results: 1 OPC-167832 exhibited potent inhibitory activity against the Mycobacterium tuberculosis laboratory strains H37Rv and Kurono, with a MIC of 0.0005 μg/mL for both, while it had almost no antibacterial activity against standard strains of aerobic and anaerobic non-mycobacterial bacteria. 2 The IC?? of OPC-167832 against intracellular Mycobacterium tuberculosis was less than 100%, and the bacteriostatic concentrations against H37Rv and Kurono strains were 0.0048 μg/mL and 0.0027 μg/mL, respectively; it could exert intracellular bactericidal effect at low concentrations, and the bactericidal activity tended to be saturated when the concentration was ≥0.004 μg/mL [1].
In vivoMethods: OPC-167832 was administered orally at doses of 0.625–10 mg/kg to detect its pharmacokinetics and lung tissue distribution; oral administration at the same doses was performed for 4 weeks to observe changes in lung tissue CFU; intragastric administration of 2.5 mg/kg combined with DCMB was conducted for 12 weeks to evaluate the combined therapeutic effect. Results: 1 OPC-167832 had good pharmacokinetic properties after oral administration, with a time to peak concentration (tmax) of 0.5–1.0 h and an elimination half-life (t1/2) of 1.3–2.1 h; the drug concentration in the lungs was approximately twice that in the plasma, and the Cmax and AUCt in both plasma and lungs were dose-dependent. 2 Compared with the vehicle group, OPC-167832 (0.625–10 mg/kg, oral administration, 4 weeks) significantly reduced lung CFU, and the lung CFU decreased in a dose-dependent manner within the dose range of 0.625–2.5 mg/kg. 3 OPC-167832 (2.5 mg/kg, intragastric administration, combined with DCMB, 12 weeks) showed the optimal therapeutic effect; the lung CFU of mice was below the detection limit after 6 weeks of treatment, and the lung bacteria of all mice were eradicated after 8 weeks of treatment [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 144 mg/mL (315.21 mM), Sonication is recommended.
KeywordsOPC-167832
Inhibitors RelatedNeomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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