Product Details
| Product Name:
OTS964 |
CAS No.:
1338542-14-5 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | OTS964 |
| Description | OTS964 is a potent, orally active compound that operates as a highly selective inhibitor of TOPK with an IC 50 of 28 nM [1]. Additionally, it demonstrates significant inhibitory action against cyclin-dependent kinase CDK11, specifically binding to CDK11B with a K d of 40 nM [2]. |
| In vitro | OTS964 treatment at a concentration of 10 nM for 48 hours has been shown to effectively suppress the proliferation of cancer cells and increase cancer cell death in LU-99 cells, as reported in study [1]. Moreover, when OTS964 is administered to Hs683 and H4 cells at varying concentrations (0.1, 1, and 2 μM) for 24 and 48 hours, it significantly upregulates the expression of LC3-II and downregulates P62 expression in a dose-dependent manner, as demonstrated in study [3]. This indicates OTS964's strong potential in inducing autophagy and promoting apoptotic processes in cancer cells. |
| In vivo | OTS964, administered intravenously at a dosage of 40 mg/kg on days 1, 4, 8, 11, 15, and 18, leads to continuous tumor shrinkage post-treatment, culminating in complete regression in nude mice bearing LU-99 lung cancer cells [1]. Similarly, oral administration of OTS964 at daily doses of 50 or 100 mg/kg for two weeks results in complete tumor regression in the same animal model [1]. These findings highlight the efficacy of OTS964 in inducing complete regression of LU-99 lung cancer cells in nude mice, regardless of the route of administration. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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$38.00
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VIP6Y
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TargetMol Chemicals Inc.
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2026-05-25 |
United States