Ozanimod Impurity; 2251699-84-8

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E-mail: anna@molcoo.com

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• Ozanimod Impurity 44

• Product Information

• Product Code: O036044

• English Name: Ozanimod Impurity 44

• English Alias: 2-isopropoxy-5-(3-(1-oxo-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

• CAS No.：2251699-84-8

• Molecular Formula: C??H??N?O?

• Molecular Weight: 359.38

• Advantages

• High Purity: HPLC ≥99.0%, confirmed by NMR (1H, 13C, HSQC) and HRMS.

• Stability: Shelf life of 24 months at -20℃, with <0.5% degradation in DMF over 3 months.

• Regulatory Compliance: Meets ICH Q3D for risk-based impurity control in novel drugs.

• Applications

• Impurity Profiling: Used in LC-MS for Ozanimod API analysis, ensuring ≤0.1% limit.

• Synthesis Monitoring: Tracks oxadiazole ring formation during indene condensation steps.

• Safety Assessment: Evaluates potential immunomodulatory effects via in vitro assays.

• Background Description

• Ozanimod, a S1PR modulator for inflammatory diseases, may generate this impurity from isopropoxy substitution or oxadiazole cyclization. Strict control is vital for clinical safety.

• Research Status

• Detection: UPLC-MS/MS with C18 column (1.7μm); LOD: 0.002 ng/mL.

• Formation Mechanism: Arises from incomplete indene oxidation; using controlled oxidation conditions reduces content by 60%.

• Biological Activity: In vitro tests show minimal S1PR binding; ongoing PK/PD studies in animals.

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

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