What Does P21 Do?

In the simplest terms, P21 boosts cognition and protects the central nervous system from

damage. It appears to do this by boosting the maturation of neurons from precursor cells

into full-fledged neurons. It also appears to boost synaptogenesis or the interconnection

between neurons, which is a fundamental component of learning and strengthening

memory.

In more specific terms, the molecule has a host of benefits on learning,memory, and

cognitive function. In mouse models, for instance, P21 enhances object discrimination

and improves spacial reasoning. It has been shown to boost levels of brain-derived

neurotrophic factor and neurotrophin-4. It has been shown in animal studies to boost

levels of synapsin 1, GluR1, and NR1, all of which are markers of neurogenesis and

synapse formation. Interestingly, it boosts levels of these proteins in disease, but boosts

them to supraphysiologic levels in health, suggesting that P21 may aid learning and

memory even in healthy brains.

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