Pachymic acid NEW
| Price | $31 | $93 | $156 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: Pachymic acid | CAS No.: 29070-92-6 |
| Purity: 99.43% | Supply Ability: 10g |
| Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | Pachymic acid |
| Description | Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways. |
| Cell Research | The anti-proliferative ability of PA on lung cancer cells was assessed by MTT, colony formation and EdU proliferation assays; cell cycle changes were detected by flow cytometry; apoptosis was detected by annexin V/PI double staining and DNA laddering; and the expression of apoptosis-related proteins was analyzed by Western blotting [1]. |
| In vitro | Porinic acid (PA) exerted antitumor effects on NCI-H23 and NCI-H460 lung cancer cells in vitro, while inducing cellular G2/M phase arrest and apoptosis. Our data showed that PA induced reactive oxygen species (ROS) production, leading to activation of c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells. Furthermore, blocking ROS production reversed PA-induced JNK and ER stress activation. Finally, PA inhibited the growth of NCI-H23 xenograft tumors without causing any toxicity to the host, and suppressed cell proliferation and induced apoptosis in tumor xenograft tissues [1]. At the same time, PA induced cell cycle arrest at G0 phase.PA also significantly inhibited cancer cell migration and invasion in a dose-dependent manner. Interestingly, PA inhibited the adhesion ability of cancer cells in a dose-dependent manner, which may contribute to the inhibition of cell invasion. Finally, it was shown that PA inhibited AKT and ERK signaling pathways. And tumor proteins such as PCNA, ICAM-1 and RhoA, which are involved in tumorigenesis, were also down-regulated by PA [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 9.52 mg/mL (18 mM), Sonication is recommended. |
| Keywords | Protein kinase B | PKB | Pachymic acid | Inhibitor | inhibit | Extracellular signal regulated kinases | ERK | Akt |
| Inhibitors Related | Aceglutamide | Musk ketone | Stearamide | Urea | Bisphenol A | Gum arabic | Hyaluronic acid | Lactose | Ethyl linoleate | Methyl eugenol | Gluconate Calcium | 2,3-Butanediol |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Natural Product Library | Miao medicine Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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