Pafuramidine NEW
| Price | $98 | $247 | $376 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Pafuramidine | CAS No.: 186953-56-0 |
| Purity: 98.34% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Pafuramidine |
| Description | Pafuramidine (DB289) is an experimental prodrug of the orally active metabolite DB75, a potent antiparasitic compound with anti-malarial activity used in the study of parasitic infections and sleeping sickness. |
| In vitro | The results of this investigation suggest that DB75 inhibits mitochondrial function. Yeast cells relying upon mitochondrial metabolism for energy production are especially sensitive to DB75 [1]. |
| In vivo | In monkeys infected with Trypanosoma cruzi, treatment with oral Pafuramidine at doses of 1, 3 and 10 mg/kg for five consecutive days on the seventh day post-infection (p.i.) of early infection showed that Pafuramidine treatment benefited most of the monkeys, and at the end of the experiment all monkeys except group 1 had improved body weights and PCVs, and in some individuals parasitemia and cerebrospinal fluid parasitemia had cleared. [1] |
| Storage | Store at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 33.33 mg/mL (91.47 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.49 mM), Sonication is recommended. |
| Keywords | Pafuramidine | P. falciparum | DB-289 | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Metronidazole | 2-Amino-2-methyl-1-propanol | Doxycycline | Penicillin G sodium salt | Fenpyroximate | Ethyl acetoacetate |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | ReFRAME Related Library | Antibiotics Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1520.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-05-11 | |
| $1.00 |
VIP7Y
|
Career Henan Chemical Co
|
2019-12-26 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY