Product Details
| Product Name:
PAT-505 |
CAS No.:
1782070-22-7 |
| Purity:
98.84% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | PAT-505 |
| Description | PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma). |
| In vivo | PAT-505 is an effective, selective, and non-competitive inhibitor, exhibiting significant inhibition of ATX activity in plasma and liver tissues upon oral administration. Therapeutic dosing of PAT-505 in Stelic mice model of non-alcoholic steatohepatitis (NASH) resulted in a modest but significant improvement in fibrosis, with only slight improvements in hepatocyte ballooning and liver inflammation. In choline-deficient, high-fat NASH diet model, PAT-505 treatment effectively reduced liver fibrosis, without significant effects on steatosis, hepatocyte ballooning, or inflammation[1]. |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (63.3 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (8.44 mM), Sonication is recommended.
|
| Keywords | PAT-505 | PAT505 | PAT 505 | EGFR | Autotaxin |
| Inhibitors Related | Balipodect | Theophylline monohydrate | D(+)-Raffinose pentahydrate | Theobromine | Apremilast | Erlotinib | Isoprenaline hydrochloride | Neratinib | Indomethacin | Gefitinib | Sildenafil citrate | Doxofylline |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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