Product Details
| Product Name:
PD 168368 |
CAS No.:
204066-82-0 |
| Purity:
99.87% |
Supply Ability:
10g |
| Release date:
2026/07/13 |
Product Introduction
Bioactivity
| Name | PD 168368 |
| Description | PD 168368 is a novel, potent, competitive and selective nonpeptide neuromodulin B receptor (NMB-R) antagonist with inhibitory effects on the gastrin-releasing peptide receptor (GRPR).PD 168368 is a potent mixed agonist of FPR1/FPR2/FPR3. |
| In vitro | PD 168368 exhibits high activity and induces [Ca2+]I release in human neutrophils, with EC50 values in the nanomolar range[3].
In the human breast cancer cell line MDA-MB-231, PD 168368 suppresses migration and invasion. It also reduces epithelial-mesenchymal transition (EMT) by upregulating E-cadherin and downregulating vimentin. At a concentration of 5 μM, PD 168368 inhibits migration and invasiveness in breast cancer cells[4].
Furthermore, at a concentration of 10 μM, PD 168368 suppresses the activation of the mTOR/p70S6K/4EBP1 and AKT/GSK-3β pathways in breast cancer cells[4]. |
| In vivo | In mice, PD 168368 potently inhibits the in vivo metastasis of breast cancer. Administered at a dose of 1.2 mg/kg through intraperitoneal injection for 30 days, PD 168368 effectively inhibits breast cancer metastasis[4]. |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (36.06 mM), Sonication is recommended.
DMF : 5 mg/mL (9.01 mM), Sonication is recommended.
|
| Keywords | PD-168368 | PD 168368 | BombesinReceptor | Bombesin Receptor |
| Inhibitors Related | Bag-1 | BA 1 acetate(183241-31-8 free base) | ML-18 | Bombesin acetate(31362-50-2 free base) | Litorin | kuwanon G | Kuwanon H | Litorin acetate(55749-97-8 Free base) | CD80-IN-3 | [D-Phe12]-Bombesin acetate | PD176252 | [D-Phe12,Leu14]-Bombesin acetate |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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