PDMP hydrochloride NEW
| Price | $399 |
| Package | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-26 |
Product Details
| Product Name: PDMP hydrochloride | CAS No.: 73257-80-4 |
| Supply Ability: 10g | Release date: 2026/05/26 |
Product Introduction
Bioactivity
| Name | PDMP hydrochloride |
| Description | PDMP hydrochloride is a ceramide analog originally developed as an inhibitor of glucosylceramide synthase that contains four stereoisomers due to two adjacent chiral centers, and while total PDMP hydrochloride inhibits glucosylceramide synthase by approximately 90% at 0.8 μM in MDCK cell homogenates, the inhibitory activity resides in the D-threo (1R,2R) enantiomer, which also blocks β-1,4-galactosyltransferase 6, prevents lactosylceramide-driven neuroinflammation in experimental autoimmune encephalomyelitis, additionally, PDMP hydrochloride enhances curcumin-induced antiproliferative and pro-apoptotic effects in melanoma cells. |
| In vitro | In experimental assays utilizing human Acute Myeloid Leukemia (AML) cells, PDMP hydrochloride was applied at concentrations ranging from 10 to 25 μM in combination with the BCL-2 inhibitor ABT-737. This treatment regimen effectively sensitized the cells to ABT-737-induced cytotoxicity, resulting in enhanced mitochondrial apoptosis [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF : 25 mg/mL (58.54 mM), Sonication is recommended. Ethanol:PBS(pH 7.2)(1:5) : 0.05 mg/mL (0.12 mM), Sonication is recommended. DMSO : 24 mg/mL (56.2 mM), Sonication is recommended. Ethanol : 50 mg/mL (117.09 mM), Sonication is recommended. |
| Keywords | PDMP |
| Inhibitors Related | Alendronate sodium trihydrate | Serotonin hydrochloride | Serotonin | D(+)-Raffinose pentahydrate | Risedronic Acid | 3-Methoxybenzamide | Entacapone | CBHcy | Eliglustat hemitartrate | (-)-Gallocatechin gallate | Flopropione | Tolcapone |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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