Peficitinib hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Peficitinib hydrochloride | CAS No.: 1353219-06-3 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Peficitinib hydrochloride |
| Description | Peficitinib hydrochloride, also known as ASP015K, is an orally active JAK inhibitor compound. It exhibits inhibitory activity against JAK1, JAK2, JAK3, and Tyk2, with IC 50 values of 3.9, 5.0, 0.7, and 4.8 nM, respectively. |
| In vitro | Peficitinib hydrobromide, administered at concentrations ranging from 0 to 100 nM for three days, effectively suppresses IL-2-induced T cell proliferation in a concentration-dependent fashion, with an IC 50 of 10 nM, as demonstrated in a Cell Proliferation Assay using splenocytes from male Lewis rats [1]. Additionally, at concentrations between 10 to 1000 nM, it impedes IL-2-induced STAT5 phosphorylation, displaying a mean IC 50 of 124 nM in rat whole blood and 127 nM in human lymphocytes, indicating its inhibitory action on STAT5 phosphorylation in both rat and human cells [1]. |
| In vivo | Peficitinib hydrobromide administered orally at doses ranging from 1-30 mg/kg once daily for 24 days demonstrated dose-dependent efficacy in both prophylactic and therapeutic protocols within an adjuvant-induced arthritis (AIA) rat model. Using seven-week-old female Lewis rats, the study quantitatively assessed the compound’s impact on disease markers: it significantly reduced paw volume starting at 1 mg/kg, with an ED50 of 2.7 mg/kg (95% confidence interval: 1.5–4.2 mg/kg), and notably decreased bone destruction scores at doses of 10 mg/kg or higher. At the maximum dose of 30 mg/kg, peficitinib hydrobromide effectively mitigated both paw swelling and bone damage, showcasing substantial therapeutic potential in the AIA model. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Delgocitinib | Ruxolitinib | Atinvicitinib | Tofacitinib Citrate | Resveratrol | 2-(1,8-naphthyridin-2-yl)phenol | Filgotinib | JAK-IN-10 | Tofacitinib | 2,4,5-Trimethoxybenzoic acid | Lentinan | Raspberry ketone glucoside |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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