Factory Provide Raw Material Antiviral Drug Powder CAS 39809-25-1 Penciclovir

Introduction

Product Name : Penciclovir 

Other name:9-[4-hychoxy-3-(hydvoxymethyl)butyl]guanine;BRL-39123;BRL-39123A;PCV;Vectavir;PENCICLOVIR-D4

CAS No.: 39809-25-1

Molecular Formula: C10H15N5O3

Molecular Weight: 253.26

Specification:99%

Appearance: White powder or crystal 

Melting Point :275-277°C (rough estimate)

Boiling Point :653.4±65.0 °C(Predicted)

Density: 1.68±0.1 g/cm3(Predicted)

Storage :Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Penciclovir, is a white crystalline solid chemical with the chemical formula 9-[4-hydroxy-3-(hydroxymethyl)-butyl]-guanine , molecular formula C10H15N5O3, molecular weight 253.25800. soluble in dimethyl sulfoxide, slightly soluble in water, very slightly soluble in ethanol, insoluble in methanol, chloroform or ethyl acetate; slightly soluble in Slightly soluble in 0.1 mol/L hydrochloric acid solution or 0.1 mol/L sodium hydroxide solution, melting point 275~277oC. Penciclovir is mainly used clinically for herpes simplex and genital herpes on the mouth, lips or face.

Application

Vectavir was launched in the UK for herpes labialis. Penciclovir is synthetically available by two routes of four steps each from 2- (hydroxymethyl)butane-l,4-diol and is active against HSV-1, HSV-2 VZV but has limited activity against CMV. Vectavir is an acyclic guanosine analog that acts as a competitive inhibitor of DNA polymerase. It is a metabolic product of famcyclovir that is preferentially phosphorylated by viral infected cells (by thymidine kinases) over normal cells. The triphosphate has a low activity against cellular DNA polymerase which is one possible explanation for its low toxicity. While its spectrum of activity is similar to acyclovir, it is longer acting because its triphosphate is 20 times more stable and is not metabolized.