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Postion:Product Catalog >Petosemtamab
Petosemtamab
  • Petosemtamab

Petosemtamab NEW

Price $355 $928 $1490
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-21

Product Details

Product Name: Petosemtamab CAS No.: 2213450-26-9
Purity: > 95% Supply Ability: 10g
Release date: 2026/05/21

Product Introduction

Bioactivity

NamePetosemtamab
DescriptionPetosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab can be used in the study of solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).
In vitroTreatment with MCLA-158(Petosemtamab) (1 μg/mL; 24 or 72 hours) induces the degradation of EGFR in EGFR+/LGR5+ colorectal cancer organoids[2].
In vivoTreatment with MCLA-158(Petosemtamab) (25 mg/kg/week, intravenous injection, for 6 weeks) leads to tumor regression in esophageal squamous cell carcinoma, gastric adenocarcinoma, and head and neck PDX models[2].
StorageStore at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
KeywordsPetosemtamab | MCLA-158 | MCLA158 | EGFR
Inhibitors Related(S)-Afatinib | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Erlotinib hydrochloride | Erlotinib | Neratinib | Afatinib | Chalcone | Brigatinib | Genistein | Gefitinib

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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