PF-04620110 NEW
| Price | $58 | $107 | $218 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: PF-04620110 | CAS No.: 1109276-89-2 |
| Purity: 98.81% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | PF-04620110 |
| Description | PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
| In vitro | Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. [1] Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. [2] |
| In vivo | In Rats, PF-04620110 reduces plasma triglyceride levels t doses of ≥0.1 mg/kg following a lipid challenge. [1] DGAT1 inhibition by PF-04620110 causes an enrichment of polyunsaturated fatty acids within the TG class of lipids in rodents. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 19.8 mg/mL (49.94 mM), Sonication and heating are recommended. |
| Keywords | PF-04620110 | mono- acylglycerol acyltransferase | Inhibitor | inhibit | Diglyceride acyltransferase | Diacylglycerol acyltransferase | DGAT1 | Acyltransferase | acyl-CoA:cholesterol acyltransferase |
| Inhibitors Related | Alendronate sodium trihydrate | Serotonin hydrochloride | D(+)-Raffinose pentahydrate | 2,2'-Methylenebis(6-tert-butyl-4-methylphenol) | Risedronic Acid | Cyclandelate | Entacapone | CBHcy | 2-Furoic acid | Eliglustat hemitartrate | Flopropione | Tolcapone |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Multi-Target Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Metabolism Compound Library | Orally Active Compound Library | Lipid Metabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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