Product Details
| Product Name:
PFM01 |
CAS No.:
1558598-41-6 |
| Purity:
99.76% |
Supply Ability:
10g |
| Release date:
2026/07/21 |
Product Introduction
Bioactivity
| Name | PFM01 |
| Description | PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). |
| In vitro | PFM01 (100 μM) treatment allows normal DSB repair in HR-defective ATMi-treated or HSC62 (BRCA2-defective) cells[1].
RAD51 foci did not form following exo- or endo-inhibitor treatment (mirin or PFM01) in 1BR3 (WT) and HSC62 (BRCA2-defective) cells[1].
PFM01 (100 μM) enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells[1].
PFM01 substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4 mg/mL (13.63 mM), Sonication is recommended.
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| Keywords | PFM-01 | PFM01 | PFM 01 | NHEJ | N-alkylated | MRE11 | Mirin | Inhibitor | inhibit | endonuclease | DSB | derivative |
| Inhibitors Related | PFM39 | T4 endonuclease VII | Endonuclease IV | Deoxyribonuclease II | PFM03 | O-Glycoprotease | AD16 | MU147 | MUS81-IN-1 | MU1409 | FEN1-IN-SC13 | T5 Exonuclease |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max | High-Efficiency Gene Editing Small Molecule Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States