Phenylephrine hydrochloride NEW
| Price | $73 |
| Package | 500mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-26 |
Product Details
| Product Name: Phenylephrine hydrochloride | CAS No.: 61-76-7 |
| Purity: 99.97% | Supply Ability: 10g |
| Release date: 2026/05/26 |
Product Introduction
Bioactivity
| Name | Phenylephrine hydrochloride |
| Description | Phenylephrine hydrochloride (NCI-c55641) is a selective agonist of the α1-adrenergic receptor. |
| In vivo | Phenylephrine protects cardiomyocytes from serum deprivation and hypoxia. It induces rapid translocation of PKC-epsilon (EC 50= 0.9 mM), with a lesser fraction lost compared to ET-1, and prevents downregulation of Bcl-X and Bcl-2 mRNA/proteins while inducing hypertrophic growth. Phenylephrine dose-dependently increases contractile force in hyperosmotic cells at pCa 7, which is reversible upon phentolamine addition. The protective effects mediated by Phenylephrine are inhibited by the PI 3-kinase inhibitor wortmannin and mimicked by the caspase-9 peptide inhibitor LEHD-fmk. It stimulates phosphoinositide hydrolysis, cellular growth, and expression of various genes associated with cardiac hypertrophy, such as atrial natriuretic factor. Phenylephrine-induced NOi release requires stimulation by IP3 and PI-3K/Akt-dependent calcium signaling, and it also enhances localized sarcoplasmic reticulum calcium release through IP3-dependent signaling. Induction of NOi release by Phenylephrine is inhibited by 1 mM prazocin, 10 mM W-7, 10 mM L-NIO, 10 mM LY294002, 2 mM H-89, 5 mM thapsigargin, 10 mM ryanodine, 2 mM 2-APB, or 10 mM xestospongin C. Additionally, 1 μM Phenylephrine significantly enhances HGF-induced hepatocyte DNA synthesis and proliferation. Finally, 1 mM Phenylephrine reversibly increases peak I(Ca,L) by 51.3% (N=40) and shifts the activation voltage by -10 mV. |
| Storage | Keep away from direct sunlight,Store under nitrogen,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 252.5 mg/mL (1239.75 mM), Sonication is recommended. H2O : 20.4 mg/mL (100.16 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.82 mM), Sonication is recommended. |
| Keywords | α1-adrenergic receptor | NCI-c55641 | EndogenousMetabolite | Endogenous Metabolite | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Guanidine thiocyanate | Malic acid | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bitter Compound library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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