PI-103 Hydrochloride NEW
| Price | $34 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-15 |
Product Details
| Product Name: PI-103 Hydrochloride | CAS No.: 371935-79-4 |
| Purity: 97.07% | Supply Ability: 10g |
| Release date: 2026/07/15 |
Product Introduction
Bioactivity
| Name | PI-103 Hydrochloride |
| Description | PI-103 Hydrochloride is a dual PI3K/Akt and mTOR inhibitor exhibiting nM-level inhibition of p110α, p110β, p110δ, p110γ, DNA-PK, mTORC1, and mTORC2. PI-103 induces autophagy, mitochondrial apoptosis, and cell cycle arrest, making it suitable for leukaemia research. |
| In vitro | PI-103 Hydrochloride exhibits anti-proliferative properties in a panel of Homo sapiens cancer cell lines (including prostate cancer, ovarian cancer, glioblastoma, and oropharyngeal squamous cell carcinoma) as well as in Homo sapiens umbilical vein endothelial cells [1]. PI-103 Hydrochloride demonstrates dose-dependent inhibition of proliferation in 37-31E and 37-31E-F3 cells. For 37-31E cells, proliferation growth can be inhibited by 50% when the PI-103 Hydrochloride concentration exceeds 100 nM, whereas the concentration required to achieve 50% inhibition in 37-31E-F3 cells is 40±2 nM. In the 37-31E-F3 cell line, the inhibitory effects of PI-103 Hydrochloride at concentrations of 50 nM and 100 nM are comparable to those achieved with 500 nM PI-103 Hydrochloride in the 37-31E cell line [4]. |
| In vivo | An orthotopic xenograft model was established by subcutaneously injecting 37-31E-F3 melanoma cells into immunocompetent FVB/N wild-type mice. Subsequent drug administration to the mice showed the following results: PI-103 Hydrochloride (10 mg/kg) significantly promoted in vivo tumor growth, while sorafenib (50 mg/kg) inhibited tumor growth. Compared with sorafenib monotherapy, the combined treatment with the two drugs did not exhibit additional benefits in terms of tumor inhibitory effect; furthermore, the tumor volume in the combined treatment group was even slightly larger than that in the sorafenib monotherapy group [4]. |
| Storage | Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3 mg/mL (7.8 mM), Sonication and heating are recommended. H2O : < 1 mg/mL (insoluble) |
| Keywords | PI-103 Hydrochloride | PI 103 Hydrochloride |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Ethyl linoleate | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | PI3K-AKT-mTOR Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | ReFRAME Related Library | Kinase Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, USA
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