PIN1 inhibitor API-1 NEW
| Price | $55 | $129 | $247 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: PIN1 inhibitor API-1 | CAS No.: 680622-70-2 |
| Purity: 98.48% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | PIN1 inhibitor API-1 |
| Description | PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM) that retains the active conformation of pXPO5, restoring its ability to transport pre-miRNAs from the nucleus to the cytoplasm, thereby up-regulating anticancer miRNA biogenesis to suppress hepatocellular carcinoma development both in vitro and in vivo. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain, effectively inhibiting Pin1 cis-trans isomerizing activity. |
| In vitro | PIN1 inhibitor API-1 significantly suppresses SK-Hep-1, SNU-423, and Hep3B cell proliferation (IC50=0.683-4.16 μM)[1]. |
| In vivo | PIN1 inhibitor API-1 inhibits tumor growth by up-regulating mature miRNA biogenesis in mice [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 10 mg/mL (27.3 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (27.3 mM), Solution. DMSO : 230 mg/mL (627.9 mM), Sonication is recommended. |
| Keywords | PIN1 inhibitor API-1 | PIN-1 inhibitor API-1 | PIN1 inhibitor API1 | PIN1 inhibitor API 1 | Pin1 | miRNA | MicroRNA | Inhibitor | inhibit |
| Inhibitors Related | Lin281632 | Guanosine-5'-triphosphate disodium salt | Rubone | TGP-377/421 | MicroRNA-21-IN-2 | Enoxacin | Camptothecin | Aurintricarboxylic acid | RJW100 | Diosgenin | Pseudoprotodioscin | Enoxacin hydrate |
| Related Compound Libraries | Bioactive Compound Library | Epigenetics Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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