Product Details
| Product Name:
Pipoxazole |
CAS No.:
91595-86-7 |
| Purity:
99.87% |
Supply Ability:
10g |
| Release date:
2026/05/16 |
Product Introduction
Bioactivity
| Name | Pipoxazole |
| Description | Pipoxazole (COR-32-24) is an adrenergic receptor agonist that can be used to study depression. |
| In vivo | Fixed small doses of radiolabeled COR3224 (14C)COR3224, 0.06 pM) were used for brain uptake assessment in rats and different concentrations of unlabeled COR3224 (5, 10, 20, and 40 μM) were added to the injection mixture by rapid intracarotid injection technique, COR3224 showed concentration-dependent brain uptake properties, indicating the existence of a carrier-mediated transport mechanism for carrier-mediated transport mechanism across the blood-brain barrier (BBB). The brain uptake index (BUI) of labeled COR3224 gradually decreased from 10.15% to approximately 5.4% as the concentration of unlabeled COR3224 increased. [1];Adult male rats (250-300gr, Sprague Dawley) were orally administered 10, 40, and 160 mg/kg radiolabeled 14C-COR3224 (30 microCi/kg) in aqueous solution and after 0.25; 0.5; 0.75; 1; 2; 4; 6; 8; 12; 16; 24; and 30 hr (5 doses of rats per session ) when sacrificed. A linear relationship was found between AUC and the doses used for TR and UP plasma assays. In contrast, brain AUC for TR and U.P was not proportional to dose, and the evolution of brain/plasma concentration ratios showed higher values for the 10 mg/kg dose than for the 40 and 160 mg/kg doses. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Pipoxazole | COR 3224. Pipoxazole | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Trifluoperazine dihydrochloride | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Atenolol | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Neurotransmitter Receptor Compound Library | Endocrinology-Hormone Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Adrenergic Receptor-Targeted Compound Library | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
|
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States