PIT-1 NEW
| Price | $30 |
| Package | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-04 |
Product Details
| Product Name: PIT-1 | CAS No.: 53501-41-0 |
| Supply Ability: 10g | Release date: 2025/07/04 |
Product Introduction
Bioactivity
| Name | PIT-1 |
| Description | PIT-1 is a selective PIP3 antagonist that inhibits cancer cell survival and induces apoptosis by inhibiting PIP3-dependent PI3K/Akt signalling and the PH structural domain of Akt. |
| In vitro | In breast cancer cell lines such as MCF-7, PIT-1 (10–100?μM, 24–48?h) induces apoptosis, reduces cell viability, and significantly downregulates the expression of Pit-1 target genes, including GH, PRL, and GHRHR. Additionally, PIT-1 upregulates pro-apoptotic genes such as Bax and activates caspase-3, suggesting PIT-1 induces apoptosis through a mitochondrial pathway[1]. |
| In vivo | In a breast cancer xenograft model using nude mice, PIT-1 (intraperitoneal injection) significantly inhibited tumor growth, reducing tumor volume by approximately 60% compared to the control group, with no apparent toxicity[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (142.14 mM), Sonication is recommended. |
| Keywords | PIT-1 | PIT 1 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | Acetylcysteine | L-Glutamic acid monosodium salt monohydrate | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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