PKR activator 1 NEW
| Price | $1520 |
| Package | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: PKR activator 1 | CAS No.: 2283420-62-0 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | PKR activator 1 |
| Description | PKR activator 1 is a potent activator of pyruvate kinase-R (PKR). |
| In vitro | Four isoforms of Pyruvate kinase (PK) are found in mammals: L and R isoforms, produced by the PKLR gene, are expressed in the liver and red blood cells, respectively. The PKM gene is responsible for two splice variants: M1, prevalent in most adult tissues, and M2, found during embryonic development and in specific adult tissues, such as the kidney and hematopoietic stem cells. Additionally, many tumor cells express PKM2. This tetrameric isoform, which is allosterically regulated, is naturally predisposed to suppress its activity through several mechanisms: post-translational modifications, allosteric alterations by small molecules including certain amino acids, and conversion into a dimeric form. These processes lead to a partial blockade of glycolysis at its final stage[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PKR activator 1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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