Plerixafor octahydrochloride NEW
| Price | $42 | $58 | $105 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Plerixafor octahydrochloride | CAS No.: 155148-31-5 |
| Purity: 98.01% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Plerixafor octahydrochloride |
| Description | Plerixafor octahydrochloride (JM3100 octahydrochloride) blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. Plerixafor is a bicyclam with hematopoietic stem cell-mobilizing activity. |
| Cell Research | Plerixafor is dissolved in DMSO and then diluted with appropriate medium[2]. U87 mg cells are seeded in 96-well plates at the density of 6×103 cells in 200 μL/well and treated with CXCL12, Plerixafor or with peptide R, as described in the previous "Treatments" section. MTT (5 μg/mL) is added at each time point (24, 48, 72 h) during the final 2 h of treatment. After removing cell medium, 100 μL DMSO are added and optical densities measured at 595 nm with a LT-4000MS Microplate Reader. Measurements are made in triplicates from three independent experiments[2]. |
| In vitro | AMD 3100 can inhibit the replication of low-passage clinical HIV-1 isolates (K31, D370, K6/-2, HEM, and JRCSF) in primary T4 lymphocytes (EC50s: 0.16-1.5 ng/ml; EC90s: 0.36-4.7 ng/ml). In primary monocytes, AMD 3100 was active against HIV-1 (K31 and SF-162) at EC50s of 0.28-7.2 ng/mL and EC90s of 0.68-12 ng/mL. |
| In vivo | Serum drug levels in rabbits given AMD 3100 (10 mg/kg) by the subcutaneous route were determined by a bioassay based on the EC50 of the compound required to inhibit HIV-1 cytopathicity in MT-4 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Insoluble H2O : 242.5 mg/mL (305.24 mM), Sonication is recommended. |
| Keywords | VirusProtease | Virus Protease | SID-791 Octahydrochloride | SID791 Octahydrochloride | SID-791 | SID791 | SID 791 Octahydrochloride | SID 791 | Plerixafor octahydrochloride | Plerixafor | JM-3100 Octahydrochloride | JM3100 Octahydrochloride | JM-3100 | JM3100 | JM 3100 Octahydrochloride | JM 3100 | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | CXCR4 | CXCR | CXCL12 | CXC chemokine receptors | AMD-3100 Octahydrochloride | AMD3100 Octahydrochloride | AMD3100 8HCl | AMD-3100 | AMD3100 | AMD 3100 Octahydrochloride | AMD 3100 |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Emtricitabine | Phenytoin sodium | Dimethyl fumarate | Lamivudine | L-Lysine | Valproic Acid | (-)-Epigallocatechin Gallate | Thymidine | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | GPCR Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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