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Postion:Product Catalog >Surfactant>Non-ionic surfactants>Polyol ester type>Polyoxyethylene stearate
Polyoxyethylene stearate
  • Polyoxyethylene stearate

Polyoxyethylene stearate NEW

Price $29
Package 5g
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Polyoxyethylene stearate CAS No.: 9004-99-3
Purity: polymer Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NamePolyoxyethylene stearate
DescriptionPolyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
In vitroPolyoxyethylene stearate modulates P-gp ATPase activity in a concentration-dependent manner, reducing P-gp mediated efflux, notably enhancing the efficacy of substances like vinblastine sulfate by limiting their expulsion from cells. This compound is also recommended to augment the radiolabelled 7H12 Middlebrook TB media, significantly promoting mycobacterial growth in the BACTEC rapid culture system. Its effectiveness extends across various mycobacterial species beyond M. tuberculosis. Specifically, at concentrations of 100 or 150 μg/mL, polyoxyethylene 40 stearate substantially increases the cytotoxicity of vinblastine to K562/ADR cells. Moreover, polyoxyethylene (50) stearate markedly boosts mycobacterial growth rates and decreases detection times in cultures, illustrating its broad potential in enhancing antimicrobial and chemotherapeutic treatments.
In vivoIn the combination of polyoxyethylene 40 stearate and vinblastine, there is a significant reduction in both the average tumor volume and weight compared to the vinblastine group alone. The tumor growth inhibition rate markedly increases from 0.06 (vinblastine group) to 0.84 (vinblastine+polyoxyethylene 40 stearate group). Furthermore, polyoxyethylene stearate shows potential as a pharmaceutical excipient to enhance the oral bioavailability of drugs that are substrates for P-glycoprotein (P-gp) and certain cytochrome P450 (CYP) isoforms [2][3].
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL, Sonication is recommended.
DMSO : 45 mg/mL, Sonication is recommended.
KeywordsPolyoxyethylene Stearate | P-gp?(P-glycoprotein) | P-gp | Pgp | P-glycoprotein | Multidrug resistance protein 1 | MDR1 | Inhibitor | inhibit | Cluster of differentiation 243 | CD243 | Bacterial | ABCB1
Inhibitors RelatedNeomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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