POV-PC NEW
| Price | $339 | $1430 | $2660 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-17 |
Product Details
| Product Name: POV-PC | CAS No.: 121324-31-0 |
| Supply Ability: 10g | Release date: 2026/07/17 |
Product Introduction
Bioactivity
| Name | POV-PC |
| Description | POV-PC is an oxidized phospholipid that inhibits VSMC growth under high serum conditions and induces apoptosis under low serum conditions. POVPC reduces NO production and expression of CD31 and endothelial NOS, triggering ferroptosis in vascular smooth muscle cells, promoting vascular calcification. |
| In vitro | POV-PC (0-100 μM; 13 h) Inhibited VSMC growth in a dose-dependent manner. POV-PC (50 μM; 2, 4, 6 h) induced apoptosis in a time-dependent manner. [1] POV-PC (30 μg/ml) enhanced endothelial barrier breakdown caused by heat-inactivated Staphylococcus aureus (HKSA). [2] |
| In vivo | In a mouse model of acute lung injury induced by intranasal injection of HKSA, intravenous injection of POV-PC(10 mg/kg) increased HKSA-induced BAL protein content and cell count, as well as tissue expression of TNF-α, KC, IL1β and CCL2. And promoted blood vessel leakage in Evans Blue's lung infiltration monitoring. [2] |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 8 mg/mL (13.47 mM), Sonication is recommended. DMF : 8 mg/mL (13.47 mM), Sonication is recommended. Ethanol : 8 mg/mL (13.47 mM), Sonication is recommended. PBS (pH 7.2) : 8 mg/mL (13.47 mM), Sonication is recommended. |
| Keywords | POV-PC | POV PC |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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