Pranlukast NEW
| Price | $50 | $72 | $90 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Pranlukast | CAS No.: 103177-37-3 |
| Purity: 99.85% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Pranlukast |
| Description | Pranlukast (ONO-1078) is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens. |
| In vitro | Pranlukast significantly reduces the volume of injury in the cortical and hippocampal CA1 regions of the ischemic hemisphere in mice and increases neuronal density. Additionally, Pranlukast markedly thins the scar wall in the ischemic hemisphere of mice. |
| In vivo | In sensitized guinea pig tracheas, 5 mM of either Pranlukast or Zafirlukast significantly inhibited ovalbumin-induced secretion by 70% and 65%, respectively. These compounds also markedly inhibited 35SO4 release triggered by 10 mM LTD4 in a concentration-dependent manner, with Pranlukast showing a peak inhibition of 83% and Zafirlukast 78% at 10 mM, having IC50 values of 0.3 mM and 0.6 mM, respectively. Pranlukast suppressed the activation of NF-κB in 1.3% DMSO-differentiated U-937 and Jurkat cells, with inhibition rates of 40% and 30%; it also demonstrated a dose-dependent inhibition of NF-κB activation in combination with MK-571. Pranlukast and MK-571 diminished LPS-induced IL-6 production in PBMCs by approximately 65% and 15%. Additionally, Pranlukast inhibited the activation of NF-κB induced by phorbol 12-myristate 13-acetate and significantly reduced LPS-induced MUC2 mRNA expression in NCI-H292 cells, as determined by reverse transcription-polymerase chain reaction. Pranlukast also suppressed the expression of the MUC2 gene in LPS-stimulated HM3-MUC2 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (93.46 mM), Sonication is recommended. |
| Keywords | TNF-α | Pranlukast | ONO1078 | ONO 1078 | NF-κB | NFκB | NF-kB | NFkB | Mucin-2 | LeukotrieneReceptor | Leukotriene Receptor | Inhibitor | inhibit | ILReceptor | IL-5 | IL Receptor | Eosinophil cationic protein | CysLTR |
| Inhibitors Related | Acetylcysteine | Lidocaine | Diethylmaleate | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | Apremilast | Dexamethasone | 5-Aminosalicylic Acid | Indole-3-carbinol | Lenalidomide | Diallyl disulfide |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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