一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cells >>article
Cells

Cells

IF: 5.2
Download PDF

The Atypical Antipsychotic Lurasidone Affects Brain but Not Liver Cytochrome P450 2D (CYP2D) Activity. A Comparison with Other Novel Neuroleptics and Significance for Drug Treatment of Schizophrenia

Published:6 November 2022 DOI: 10.3390/cells11213513 PMID: 36359909
Przemys?aw J Danek, W?adys?awa A Daniel

Abstract

The aim of this work was to study the effect of prolonged lurasidone administration on the cytochrome 2D (CYP2D) expression and activity in the rat liver and selected brain structures involved in the therapeutic or side effects of this neuroleptic. Male Wistar rats received lurasidone (1 mg/kg ip.) for two weeks. The activity of CYP2D was measured in brain and liver microsomes as the rate of bufuralol 1'-hydroxylation. The CYP2D protein level was determined in microsomes by Western blot analysis. The CYP2D gene expression was estimated in liver tissue by a qRT-PCR method. Lurasidone decreased the activity and protein level of CYP2D in the frontal cortex but increased them in the striatum, nucleus accumbens, brain stem, substantia nigra, and the remainder of the brain. The neuroleptic did not affect CYP2D in the hippocampus, hypothalamus, and cerebellum. In the liver, lurasidone did not affect the CYP2D activity and protein level, though it enhanced the mRNA of CYP2D1 without affecting that of CYP2D2, CYP2D3, CYP2D4, and CYP2D5. In conclusion, lurasidone regulates brain (but not liver) CYP2D activity/protein level in a region-dependent manner, which is similar to that of other atypical neuroleptics (iloperidone and asenapine) as concerns the frontal cortex (down-regulation) and nigrostriatal pathway (up-regulation) and may be of pharmacological significance. However, further molecular studies with selective receptor agonists are necessary to find out which individual monoaminergic receptors/signaling pathways are involved in the regulation of the rat CYP2D4 and human CYP2D6 enzyme in particular brain structures.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Lurasidone hydrochloride 367514-88-3 C28H37ClN4O2S 359 suppliers $39.00-$1875.00
Lurasidone hydrochloride 367514-88-3 C28H37ClN4O2S 359 suppliers $39.00-$1875.00
Lurasidone hydrochloride 367514-88-3 C28H37ClN4O2S 359 suppliers $39.00-$1875.00
Lurasidone hydrochloride 367514-88-3 C28H37ClN4O2S 359 suppliers $39.00-$1875.00

Similar articles

西安市| 法库县| 陇西县| 苍梧县| 封开县| 西贡区| 板桥市| 常德市| 桐庐县| 岐山县| 广德县| 华蓥市| 琼海市| 恩施市| 阳城县| 呈贡县| 泌阳县| 皋兰县| 平凉市| 桃园市| 馆陶县| 云霄县| 泰州市| 台北市| 东山县| 平远县| 澄城县| 临江市| 武义县| 贵溪市| 黎川县| 蓝山县| 遂川县| 开封县| 安达市| 衡阳县| 阜新市| 贡嘎县| 商水县| 巴楚县| 尉犁县|