Product Details
| Product Name:
PS210 |
CAS No.:
1221962-86-2 |
| Purity:
99.78% |
Supply Ability:
10g |
| Release date:
2026/05/25 |
Product Introduction
Bioactivity
| Name | PS210 |
| Description | PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K. |
| In vitro | PS210 stabilized the residue Arg131 when PS210 causes stabilization of PDK1 to the temperature gradient, located opposite to the helix a-B at the other extreme of the helix a-C. So, the residues forming part of the phosphate-binding site appear to be a fixed point that allows for the relative movement of the helices in the process of PDK1 activation[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (157.77 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.26 mM), Sonication is recommended.
|
| Keywords | Thr148 | S6K | PS423 | PS-210 | PS210 | PS 210 | pocket | PIFtide | PIF-binding | PDK-1 | PDK1 | Lys76 | Inhibitor | inhibit | helix | Arg131 | a-B |
| Inhibitors Related | Rabusertib | MP7 | M77976 | Sodium dichloroacetate | RS1-PDK1 inhibitor | GSK-7227 | BX795 | Hordenine hydrochloride | Dehydroabiethylamine | Dicoumarol | Osu03012 | PS423 |
| Related Compound Libraries | Glycolysis Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Oxidation-Reduction Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$995.00
|
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-04-22 |
|
|
|
|
Wuhan Nutra Biotechnology Co.,Ltd
|
2024-11-01 |
United States