Product Details
| Product Name:
PT-262 |
CAS No.:
86811-36-1 |
| Purity:
98.81% |
Supply Ability:
10g |
| Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | PT-262 |
| Description | PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research. |
| In vitro | In A549 lung carcinoma cells, treatment with PT-262 (5-40 μM) inhibited proliferation and promoted G2/M phase arrest by inhibiting CDC2 and ERK phosphorylation. It also triggered mitochondrial dysfunction and Caspase-3 activation, leading to apoptosis [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (289.1 mM), Sonication is recommended.
|
| Keywords | PT-262 |
| Inhibitors Related | Ribociclib | TBHQ | Urea | 2-Chloropyrazine | Gum arabic | Kojic acid | L-Cysteine | Lactose | Abemaciclib | Tauroursodeoxycholate | Gluconate Calcium | β-Glycerophosphate disodium salt hydrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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