一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >PT2399
PT2399
  • PT2399

PT2399 NEW

Price $95 $235 $353
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-15

Product Details

Product Name: PT2399 CAS No.: 1672662-14-4
Purity: 99.45% Supply Ability: 10g
Release date: 2026/05/15

Product Introduction

Bioactivity

NamePT2399
DescriptionPT2399 is a potent, selective, orally available HIF-2α antagonist that directly binds to the PAS B domain of HIF-2α (IC?? = 6 nM). PT2399 exhibits antitumor activity. PT2399 specifically blocks the heterodimerization of HIF-2α and HIF-1β, thereby inhibiting the expression of downstream target genes such as VEGF and GLUT1, and exerts its antitumor effects.
In vitroMethods: HEK293T cells were co-transfected with HIF-2α G323E and HIF-1β F446L expression plasmids. After 36 hours, cells were treated with PT2399 (10 μM) for 5 hours at 37 °C. Immunoprecipitation was performed using anti-FLAG beads (A2220-1ML, Sigma), followed by Western blot analysis. Results: HIF-2α G323E and HIF-1β F446L mutations maintained HIF-2 dimer stability against PT2399-induced dissociation. [1] Methods: RAW 264.7 macrophages were induced to M2 polarization with IL-4/IL-13 (10 ng/mL). Conditioned medium collected after 48 hours of treatment with PT2399 (0.1, 1, 10 μM) in CAFs cultured under 1% O? hypoxia was used for 48-hour treatment. RT-qPCR detected Arg1 mRNA levels as an M2 marker. Results: Hypoxic CAF-conditioned medium (CM) significantly enhanced IL-4/13-induced Arg1 expression (promoting M2 polarization). Following PT2399 treatment of CAFs, the pro-M2-polarizing effect of their CM was abolished. [2]
In vivoMethods: Immunodeficient mice (NOD/SCID) were used to establish a xenograft tumor model. Following successful tumor implantation, oral gavage administration was performed (Sunitinib, 10 mg/kg; PT2399, 100 mg/kg) for 4 consecutive weeks. Results: In sensitive tumors, PT2399 significantly downregulated HIF-2 target gene expression and inhibited tumor cell proliferation and angiogenesis. [1] Methods: C57BL/6 mice were orthotopically inoculated with KPC cells in the pancreas. Following successful inoculation, oral administration of PT2399 (50 mg/kg) was administered twice daily, 5 days per week, for 3 weeks; Intraperitoneal injection of αCTLA4 + αPD1 (dual immune checkpoint blockade, DCB) every 4 days for 2 weeks, with monitoring up to 45 days. Results: The PT2399 + DCB combination therapy group achieved a 100% survival rate at 45 days, significantly higher than the control group and superior to the DCB monotherapy group. [2] Methods: Spinal disc degeneration (APD) model induced by needle puncture in SD rats. PT2399 (10 nmol/kg) administered via local injection through the puncture needle post-surgery; PT2399-PHBV/PP20 (containing equivalent PT2399) administered as a single injection. Animals euthanized at 4, 6, and 8 weeks for tissue collection. Results: In the APD+PT2399-PHBV and APD+PT2399-PP20 groups, histological scores showed a smaller increase and the height/width ratio exhibited a smaller decrease at 6 and 8 weeks, indicating a slowed degeneration process. [3]
StorageStore at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 262.5 mg/mL (626.01 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (11.92 mM), Sonication is recommended.
KeywordsPT-2399 | PT2399 | PT 2399 | Inhibitor | inhibit | Hypoxia-inducible factors | HIFs | HIFProlylHydroxylase | HIF-PH | HIF-2α | HIF/HIFProlylHydroxylase | HIF/HIF Prolyl-Hydroxylase | HIF/HIF ProlylHydroxylase | HIF Prolyl-Hydroxylase | HIF ProlylHydroxylase | HIF
Inhibitors RelatedDeferoxamine Mesylate | Hydralazine hydrochloride | Dapagliflozin | Chlorogenic Acid | Glucosamine | Hydroxycitric acid tripotassium hydrate | Glucosamine hydrochloride | Chloramphenicol | Oroxylin A | Acriflavine Hydrochloride | Albendazole | Glucosamine sulfate
Related Compound LibrariesReprogramming Compound Library | Glycolysis Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Hematonosis Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Transcription Factor-Targeted Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$347.00
VIP4Y
TargetMol Chemicals Inc.
2026-04-20
$95.00
VIP4Y
TargetMol Chemicals Inc.
2026-05-15

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY
塔河县| 克山县| 嘉峪关市| 清远市| 年辖:市辖区| 濮阳市| 孟津县| 太仓市| 砚山县| 政和县| 扶风县| 白河县| 西宁市| 昂仁县| 桦甸市| 绥化市| 社会| 铅山县| 青川县| 东源县| 扎囊县| 乐昌市| 黑龙江省| 蒙山县| 石渠县| 西林县| 保定市| 崇信县| 哈密市| 沈阳市| 堆龙德庆县| 彭阳县| 六枝特区| 连州市| 府谷县| 桃园县| 镇安县| 阜城县| 南丹县| 安西县| 环江|