Product Details
| Product Name:
QN523? |
CAS No.:
878581-60-3 |
| Purity:
99.83% |
Supply Ability:
10g |
| Release date:
2026/04/20 |
Product Introduction
Bioactivity
| Name | QN523? |
| Description | QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autophagy is a major mechanism of action. |
| In vitro | QN523 showed significant cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines. QN523 at 0.5 μM and gemcitabine at 0.1 μM arrested MIA PaCa-2 cells in the S-phase following 24 and 48 h treatment[1]. |
| In vivo | In NOD/SCID mice of MIA PaCa-2 xenografts, QN523 at 10 mg/kg (intraperitoneal administration) shows no significant delay in tumor growth from day 1 to day 9. QN523 at 20 mg/kg from day 10 and continued until day 44 delayed growth of the MIA PaCa-2 xenograft starting from day 17. On day 44 80% inhibition of tumor growth was observed. No symptoms of gross toxicity such as weakness, weight loss or lethargy were observed in the QN523 treatment group[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 16.2 mg/mL (64.73 mM), Sonication is recommended.
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| Keywords | QN523? | QN-523 | QN523 | QN 523 | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Bioactive Compound Library | Autophagy Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States