Quazinone NEW
| Price | $359 | $495 | $1120 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-07 |
Product Details
| Product Name: Quazinone | CAS No.: 70018-51-8 |
| Supply Ability: 10g | Release date: 2026/07/07 |
Product Introduction
Bioactivity
| Name | Quazinone |
| Description | Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties. |
| In vitro | Method: Isolated human ureteral strips were precontracted with 80 mM KCl, and cumulatively increasing concentrations of quazinone were added to observe the relaxation response. The EC50 value was calculated. Result: Quazinone dose-dependently relaxed isolated human ureteral strips, with an EC50 of 25 μM. At a concentration of 10 ?4 M, it produced 86.8% ± 5.4% maximal relaxation[1]. Method: Isolated human cavernosal smooth muscle strips were precontracted with 1 μM norepinephrine, and cumulatively increasing concentrations of quazinone were added to observe the relaxation response. The EC50 value and maximal relaxation effect were calculated. Result: Quazinone dose-dependently relaxed isolated human cavernosal smooth muscle strips, with an EC50 of 4.2 ± 0.6 μM. At the highest concentration tested, it produced a maximal relaxation of 100% ± 0%[2]. Method: Bovine coronary artery vascular smooth muscle cells (SMC) were rendered quiescent in serum-free medium for 3 days, then pretreated with quazinone (10 μM) for 10 min prior to stimulation with PDGF-BB (10 ng/mL). DNA synthesis inhibition was assessed by [3H] thymidine incorporation, and p42/p44 MAP kinase phosphorylation was detected by Western blotting. Result: Quazinone (10 μM) significantly inhibited PDGF-induced SMC DNA synthesis and suppressed p42/p44 MAP kinase phosphorylation. Its antimitogenic effect was completely reversed by the PKA inhibitors H89 and Rp-cAMPS[3]. |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble), Sonication is recommended. DMSO : 2.5 mg/mL (10.61 mM), Sonication is recommended. |
| Keywords | Quazinone |
| Inhibitors Related | Balipodect | Theophylline monohydrate | D(+)-Raffinose pentahydrate | Roflumilast | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Vardenafil hydrochloride | Sildenafil citrate | Doxofylline | Sodium new houttuyfonate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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CAS:135-07-9
Recommended supplier
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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