(R)-(-)-α-Methylhistamine dihydrobromide NEW
| Price | $442 |
| Package | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: (R)-(-)-α-Methylhistamine dihydrobromide | CAS No.: 868698-49-1 |
| Purity: 99.98% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | (R)-(-)-α-Methylhistamine dihydrobromide |
| Description | (R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective, and brain-penetrant agonist of the H3 histamine receptor with high receptor affinity, capable of enhancing memory retention and attenuating cognitive impairment in rat models, making it a valuable pharmacological probe for elucidating central histaminergic signaling and H3 receptor-mediated modulation of learning and memory processes. |
| In vitro | (R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist with over 10 times the potency of histamine (HA). It exhibits weak affinities for H1 and H2 receptors, with pKi values of 4.8 and <3.5, respectively. The compound shows more than 1,000 times selectivity for H3-receptors compared to HA and over 200-fold selectivity over H4 receptors[1]. |
| In vivo | In mouse and rat models, intraperitoneal (i.p.) administration of (R)-(-)-α-Methylhistamine dihydrobromide (e.g., 6.3 mg/kg) decreases the steady-state levels of tele-methylhistamine (t-MH), a primary histamine metabolite, without changing total histamine levels. This indicates an inhibition of histamine turnover. In a rat model of anesthesia-induced amnesia, pretreatment with 10 mg/kg (i.p.) reverses memory retention deficits caused by Propofol [2][3][4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | α-Methylhistamine Dihydrobromide | α-Methylhistamine | HistamineReceptor | Histamine Receptor | H3 Receptor | a-Methylhistamine Dihydrobromide | a-Methylhistamine | alpha-Methylhistamine Dihydrobromide | alpha-Methylhistamine | (R)()αMethylhistamine dihydrobromide | (R) ( ) α Methylhistamine dihydrobromide |
| Inhibitors Related | Undecane | Betahistine mesylate | Histamine dihydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Nizatidine | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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