RB-3 NEW
| Price | $2120 |
| Package | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: RB-3 | CAS No.: 2396639-11-3 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | RB-3 |
| Description | RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f with a Kd of 2.8 μM. |
| In vitro | RB-3 effectively reduces the overall ubiquitination of H2A, promoting differentiation in both leukemia cell lines and primary acute myeloid leukemia (AML) samples, with an inhibition concentration (IC 50) of 1.6 μM. Additionally, it disrupts the function of PRC1 by inhibiting its interaction with nucleosomes and attenuates colony formation in a mixed lineage leukemia (MLL)-eleven nineteen leukemia (ENL) model. Furthermore, through Western Blot Analysis on TEX cells at concentrations of 6, 12, 25 μM over 8 days, RB-3 was observed to incrementally elevate C/EBPα-p42 protein levels, indicating its potent biochemical activities relevant to leukemia research. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | RB-3 | RB 3 | RB3 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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