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Postion:Product Catalog >Biochemical Engineering>Nucleoside drugs>Nucleoside Intermediates>Regadenoson Impurity
Regadenoson Impurity
  • Regadenoson Impurity
  • Regadenoson Impurity
  • Regadenoson Impurity
  • Regadenoson Impurity
  • Regadenoson Impurity

Regadenoson Impurity NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-12-16

Product Details

Product Name: Regadenoson Impurity CAS No.: 2004-07-1
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/12/16
M.W. : C10H12ClN5O4

Regadenoson Impurity;2004-07-1

Article illustration

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com

Product Information

  • Product Code:R013030

  • English Name:Regadenoson Impurity 30

  • English Alias:(2R,3R,4S,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

  • CAS No.:2004-07-1

  • Molecular Formula:C??H??ClN?O?

  • Molecular Weight:301.69

Advantages

  • High-Purity Reference Standard:Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, suitable for Regadenoson impurity analysis and quality control.

  • Stability Assurance:Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in methanol-water mixture within 6 months.

Applications

  • Quality Control Testing:Used for UPLC-MS/MS detection of Impurity 30 in Regadenoson API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).

  • Process Optimization Research:Monitors impurity formation during Regadenoson synthesis, reducing generation by >35% by adjusting amination temperature (e.g., 60-70℃) and pH.

  • Method Validation:Serves as a standard for developing impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).

Background Description

Regadenoson, a selective A2A adenosine receptor agonist, is used for myocardial perfusion imaging to diagnose coronary heart disease. Impurity 30, a process-related impurity in its synthesis, may originate from chlorination of purine rings or glycosylation side reactions. Its amino, chlorine, and polyol groups may affect drug water solubility, stability, and receptor binding. Strict impurity control for cardiovascular drugs is critical to medication safety, making research on this impurity essential for ensuring drug quality.

Research Status

  • Detection Technology:UPLC-MS/MS with C18 column (1.7μm) and 0.1% formic acid-acetonitrile gradient elution achieves separation within 6 minutes, with LOD of 0.005 ng/mL for trace impurity analysis.

  • Formation Mechanism:Formed by nucleophilic substitution of 2,6-dichloropurine with glycosyl compounds in ammonia solution; optimizing reaction temperature and ammonia concentration inhibits side reactions.

  • Safety Evaluation:In vitro cytotoxicity shows IC?? of 178.5 μM against H9c2 cardiac cells (Regadenoson IC??=8.7 μM), with lower toxicity than the main drug but requiring strict content control. Long-term stability testing is ongoing to monitor degradation under high temperature (40℃) and high humidity (75%RH) conditions.

NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com


NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 


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