Product Details
| Product Name:
Relutrigine |
CAS No.:
2392951-29-8 |
| Purity:
99.68% |
Supply Ability:
10g |
| Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | Relutrigine |
| Description | Relutrigine (PRAX-562) is an orally active, long-acting sodium current inhibitor that preferentially suppresses sustained INa induced by TX-II or SCN8A N1768D mutations (IC50=141/75 nM). It reduces neuronal intrinsic excitability and may be used for anticonvulsant therapy. |
| In vitro | Relutrigine (0.001–10,000 μM) inhibits the hNaV1.6 sustained sodium channel with a persistent INa preference. Relutrigine (0.3 μM) significantly reduces intrinsic excitability in wild-type CA1 pyramidal neurons [1]. |
| In vivo | Relutrigine (0.3–40 mg/kg; oral; single dose) dose-dependently protected against maximal electroconvulsive seizure (MES)-induced tonic hindlimb seizures in male CD-1 mice [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (196.43 mM), Sonication is recommended.
|
| Keywords | Relutrigine | CS-038 | CS038 | CS 038 | Chiglitazar sodium |
| Inhibitors Related | Phenytoin sodium | Procaine | Ranolazine dihydrochloride | Tetracaine hydrochloride | Lidocaine | Safinamide | Permethrin | Valproic Acid | L-Aspartic aicd sodium | Lidocaine hydrochloride | Mebeverine hydrochloride | Dibucaine |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States