Resmetirom NEW
| Price | $33 | $33 | $33 | $47 | $47 | $47 | $89 | $89 | $89 |
| Package | 1mg | 1mg | 1mg | 2mg | 2mg | 2mg | 5mg | 5mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Resmetirom | CAS No.: 920509-32-6 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Resmetirom |
| Description | Resmetirom (MGL-3196) is a THR-β agonist (EC50=0.21 μM), with high selectivity and oral activity. Resmetirom can be used in the research of non-cirrhotic and non-alcoholic steatohepatitis. |
| In vitro | METHODS: CYP3A4/5, CYP2C19 and CYP2C9 were treated with Resmetirom to detect the inhibition of cell growth. RESULTS: The IC50 of ResmetiromCYP3A4/5 and CYP2C19 were both greater than 50 μM, with no growth inhibitory effect. The inhibitory effect on CYP2C9 was relatively weak, and the IC50 was approximately 22 μM. [1] |
| In vivo | METHODS: To study the effect of Resmetirom on the liver, the suspension of MGL-3196 (0.3, 1, 3, 10 mg/kg) was administered by gavage to DIO mice for 23 consecutive days. RESULTS: Resmetirom demonstrated good exposure and reasonable oral bioavailability in rats. Both the distribution volume and the clearance rate are relatively low. For the MGL-3196 suspension orally administered to DIO mice, an increased exposure in the dose ratio was observed [1]. Among the animals treated with McL-3196, both cholesterol and liver size decreased, which was mainly due to the reduction of triglycerides in the liver. Among the animals treated with McL-3196, there was no effect on bone mineral density (BMD), heart or kidney size [1]. METHODS: To study the improvement of liver pathological characteristics by Resmetirom, mouse models of non-alcoholic steatohepatitis (NASH) were treated with Resmetirom(3 mg/kg, 5 mg/kg). RESULTS: In the NASH mouse model, Resmetirom was able to significantly improve the pathological characteristics of the liver. Through the oil red O staining experiment, it was found that Resmetirom could effectively reduce liver fat accumulation, and the effect was more obvious in the high-dose group (5 mg/kg). In addition, Resmetirom can also improve liver fibrosis and inflammation caused by NASH by restoring the expression of RGS5 and inhibiting the activation of STAT3 and NF-κB signaling pathways. [2] |
| Storage | Store at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.58 mM), Sonication is recommended. DMSO : 101 mg/mL (232.07 mM), Sonication is recommended. |
| Keywords | VIA3196 | VIA 3196 | Thyroidhormonereceptor(THR) | Thyroidhormonereceptor | Thyroid hormone receptor(THR) | Thyroid Hormone Receptor | THR-β | THR | Resmetirom | MGL-3196 | MGL 3196 | Inhibitor | inhibit |
| Inhibitors Related | Azetirelin | L-Thyroxine sodium | 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE | Iopanoic acid | DS08210767 | Carbimazole | Octinoxate | Methimazole | Posatirelin | PCO371 | Tiratricol | Eneboparatide |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | Toxic Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-COVID-19 Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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