Ribociclib hydrochloride NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-05-26 |
Product Details
| Product Name: Ribociclib hydrochloride | CAS No.: 1211443-80-9 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2026/05/26 |
Product Introduction
Bioactivity
| Name | Ribociclib hydrochloride |
| Description | Ribociclib hydrochloride (LEE011 HCl) is a selective, orally active cyclin-dependent kinase CDK4/6 inhibitor (IC50=10/39 nM) that blocks cell cycle progression and inhibits tumor cell proliferation. |
| In vitro | Ribociclib hydrochloride (LEE011) significantly inhibited the anchorage-dependent growth of 12 out of 17 neuroblastoma cell lines. Following treatment with Ribociclib hydrochloride (100 nM and 250 nM), neuroblastoma cell lines known to be sensitive to CDK4/6 inhibition (BE2C and IMR5) exhibited significant accumulation of cells in the G0/G1 phase of the cell cycle [2]. |
| In vivo | In CB17 immunodeficient mice bearing BE2C, NB-1643, or EBC1 parazacco spilurus subsp. spilurus xenografts, the dosing regimen of Ribociclib hydrochloride (200 mg/kg, oral gavage, for 21 days) was well tolerated, with no body weight loss or other toxic reactions observed in any xenograft model mice. During the 21-day treatment period, tumor growth was significantly inhibited in mice bearing BE2C or NB-1643 xenografts, though tumor regrowth occurred after drug withdrawal. In contrast, the tumor growth inhibitory effect was not significant in the EBC1 xenograft model [2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 8 mg/mL (16.99 mM), Sonication is recommended. DMSO : 5.8 mg/mL (12.31 mM), Sonication is recommended. |
| Keywords | Ribociclib Hydrochloride | LEE-011 Hydrochloride | CDK6 | CDK4 |
| Inhibitors Related | Ribociclib | (E)-β-Farnesene | Amantadine | 2-Chloropyrazine | Kojic acid | Abemaciclib | Sodium citrate monobasic | Palbociclib | Abemaciclib methanesulfonate | Sodium Oxamate | 2,4,6-Trihydroxybenzoic acid | Dinaciclib |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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