一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Ripisartan
Ripisartan
  • Ripisartan

Ripisartan NEW

Price $115 $282 $413
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: Ripisartan CAS No.: 148504-51-2
Purity: 98.86% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameRipisartan
DescriptionRipisartan (UP-269-6) is a potent and specific angiotensin II receptor antagonist that inhibits angiotensin II-mediated sympathetic tachycardia responses.
In vitroUP 269-6 bound selectively to AT1 receptors as evidenced by the inhibition of specific [125I] Sar1, Ile8-AII binding in rat adrenal membranes (IC50 = 35.8 nM) and in cultured vascular smooth muscle cells (IC50 = 23.8 nM). UP 269-6 displayed a very high selectivity for the AT1 compared to the AT2 receptor subtype (IC50 >10,000 nM). UP 269-6 inhibited the AII-induced contraction of isolated rabbit aortic strips.[4] UP 269-6 at low concentrations (10(-10), 3 x 10(-10), 10(-9) M) of UP 269-6 and insurmountable antagonism at higher concentrations (3 x 10(-9), 10(-8), 3 x 10(-8) M). Based on the calculated pA2 values, UP 269-6 (9.86 +/- 0.25) was an angiotensin II receptor antagonist as potent as L-158,809 (9.82 +/- 0.37) and much more potent than losartan (7.96 +/- 0.38). UP 269-6 was devoid of affinity (IC50 > 10,000 nM) for many other receptors, ion channels and uptake sites, demonstrating its high specificity for AII receptors. Furthermore, this compound did not affect the contractile response to KCl or phenylephrine in rabbit aorta and exhibited no effect on angiotensin-converting enzyme activity. These data demonstrate that UP 269-6 is a highly potent, selective, and specific AT1 receptor antagonist.[4]
In vivoRipisartan(0.03-1 mg/kg; i.v.; rats) shifted dose-dependently to the right of the dose-pressor response curve for angiotensin II and decreased the maximum response. Ripisartanantagonized the angiotensin II sympathetic-mediated tachycardiac response.[1] Ripisartaninhibited dose-dependently the pressor response to angiotensin II with an ID50 of 4.5 micrograms/kg, i.v. in conscious normotensive dogs.[1] Ripisartan(0.1 to 30 mg/kg; Oral) resulted in a dose-dependent and long-lasting inhibition of the angiotensin II-induced pressor response in conscious normotensive rats and dogs.[1] Ripisartanis a potent and specific angiotensin II receptor antagonist and does not possess agonistic properties.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 55 mg/mL (128.97 mM), Sonication is recommended.
KeywordsUP2696 | Ripisartan | angiotensin II receptor
Inhibitors RelatedLosartan potassium | Tranilast | Enalapril Maleate | Telmisartan | Lisinopril dihydrate | Sacubitril/Valsartan | Benzyl benzoate | Irbesartan | Losartan | Ramipril | Diisononyl phthalate | Captopril
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Inhibitor Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
Anhui Ruihan Technology Co., Ltd
2023-08-21

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY
延长县| 泊头市| 容城县| 土默特右旗| 林口县| 民权县| 长丰县| 黑山县| 隆昌县| 咸宁市| 喀什市| 九江市| 青神县| 通山县| 辽宁省| 将乐县| 武汉市| 四川省| 聂荣县| 微山县| 临朐县| 资源县| 雷波县| 汾西县| 安吉县| 慈溪市| 庄河市| 沙洋县| 天台县| 辽阳市| 台东县| 德庆县| 定陶县| 伊川县| 苍溪县| 内乡县| 太仆寺旗| 长海县| 叙永县| 浦江县| 银川市|