RO2959 Hydrochloride NEW
| Price | $79 | $173 | $256 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: RO2959 Hydrochloride | CAS No.: 1219927-22-6 |
| Purity: 99.24% | Supply Ability: 10g |
| Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | RO2959 Hydrochloride |
| Description | RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2. |
| In vitro | RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (21.55 mM), Sonication is recommended. |
| Keywords | T-cell | Stim1 | SOCE | RO-2959 Hydrochloride | RO2959 Hydrochloride | RO-2959 | RO2959 | RO 2959 Hydrochloride | RO 2959 | Orai1 | IP3 | Interleukin Related | Interleukin | Inhibitor | inhibit | ILReceptor | IL-2 | IL Receptor | heart | failure | CRAC channel | CalciumChannel | Calcium release-activated channels | Calcium Channel | Ca2+ release-activated Ca2+ channels | anti-proliferation |
| Inhibitors Related | Kaolin | Quadrol | 2,4,6-Tri-tert-butylphenol | Rhamnose monohydrate | L-Ascorbic acid | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose | 1,8-Cineole | Tributyrin | L-Ascorbic acid sodium salt | Gluconate Calcium | Magnesium Chloride Hexahydrate |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Calcium Channel Compound Library | Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Hypertension Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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