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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Cell Cycle>PLK inhibitors>Ro3280
Ro3280
  • Ro3280

Ro3280 NEW

Price $52 $113 $198
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: Ro3280 CAS No.: 1062243-51-9
Purity: 97.76% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameRo3280
DescriptionRo3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).
In vitroIn nude mice implanted with HT-29 human colon tumors, RO3280 (40 mg/kg) was effective in inhibiting tumor cell proliferation.
In vivoRO3280 exhibits antitumor activity across a variety of tumor cell lines, effectively inhibiting cancer cell proliferation. Specifically, it demonstrates potency against lung cancer cell line H82 (IC50=5 nM), colorectal cancer cell HT-29 (IC50=10 nM), breast cancer cell MDA-MB-468 (IC50=19 nM), prostate cancer cell PC3 (IC50=12 nM), and skin cancer cell A375 (IC50=70 nM).
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 27.2 mg/mL (50.04 mM), Sonication is recommended.
Ethanol : 27.2 mg/mL (50.04 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.68 mM), Sonication is recommended.
KeywordsRO-3280 | Ro3280 | Polo-like Kinase (PLK) | PLK1 | PLK | Inhibitor | inhibit
Inhibitors RelatedTTK/PLK1-IN-1 | T521 | (E/Z)-Rigosertib sodium | Cyclapolin 9 | SBE13 Hydrochloride | Pyridoxine | Rigosertib sodium | 3MB-PP1 | Volasertib | Poloxin-2 | BI 2536 | GSK461364
Related Compound LibrariesHighly Selective Inhibitor Library | Bioactive Compound Library | Kinase Inhibitor Library | Hematonosis Compound Library | Multi-Target Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Fluorochemical Library | Cell Cycle Compound Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Address: 36 Washington Street, Wellesley Hill, MA
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