Product Details
| Product Name:
S130 |
CAS No.:
1160852-22-1 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | S130 |
| Description | S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux. |
| In vitro | S130 suppresses autophagy and activates apoptosis by inhibiting ATG4B, leading to enhanced cytotoxicity. S130 (0-25 μM; 48 hours) induces cell death through ATG4B inhibition at doses higher than 6.3 μM, without causing necroptosis. Nutrient deprivation enhances S130-induced cytotoxicity. S130 (0-10 μM; 24 hours) suppresses approximately 79% of full-length LC3-GST cleavage at 10 μM, while no substrates were processed in ATG4B KO cells. S130 exhibits significant inhibitory effects on ATG4B. |
| In vivo | Tumor growth suppressed by S130 (20 mg/kg; i.p.; daily; 3 weeks), S130 shows an efficient in vivo antitumor effect with a sound safety on vital organs. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (8.52 mM), Sonication is recommended.
DMSO : 125 mg/mL (322.61 mM), Sonication is recommended.
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| Keywords | S-130 | S130 | S 130 | CysteineProtease | Cysteine Protease | ATG4B |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Suppliers |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States