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Postion:Product Catalog >S65487
S65487
  • S65487

S65487 NEW

Price $1160
Package 25mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: S65487 CAS No.: 1644600-79-2
Purity: 99.03% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameS65487
DescriptionS65487 (VOB560) is a potent and selective inhibitor of the anti-apoptotic protein Bcl-2, displaying activity not only against the wild-type protein but also against clinically relevant BCL-2 mutations such as G101V and D103Y. S65487 demonstrates poor affinity toward other Bcl-2 family members, including MCL-1, BFL-1, and BCL-XL, which underlines its selectivity profile. S65487 induces apoptosis in cancer cells and exhibits robust anticancer activities in preclinical studies.
In vitroS65487 effectively induces apoptosis and inhibits proliferation in a panel of hematologic cancer cell lines by binding to the BH3 hydrophobic groove of the BCL-2 protein, with a half-maximal inhibitory concentration (IC50) in the low nanomolar (nM) range. [1]
In vivoS65487 effectively induces complete regression in BCL-2-dependent RS4;11 tumors through a single intravenous (IV) dose and demonstrates consistent, strong tumor regression in mouse and rat xenograft models of lymphoid malignancies at tolerable doses with weekly IV administrations when combined with MCL-1-specific inhibitor S64315/MIK665.[1]
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (6.97 mM), Sonication is recommended.
DMSO : 160 mg/mL (223.07 mM), Sonication is recommended.
KeywordsS-65487 | S65487 | S 65487
Inhibitors RelatedStavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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