Product Details
| Product Name:
SAR407899 |
CAS No.:
923359-38-0 |
| Purity:
99.91% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | SAR407899 |
| Description | SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries. |
| Animal Research | Compared the effects of SAR407899, the Rho-kinase inhibitor Y-27632 and the PDE5 inhibitor sildenafil for their ability to relax corpus cavernosum strips contracted with phenylephrine in healthy and diabetic animals. Strips were obtained from WKY, spontaneous hypertensive (SHR), control CD, and diabetic CD rats, humans, control and diabetic rabbits. Diabetes was induced by streptozotocin or alloxan injection. In vivo penile erection (length) induced by drugs was measured in conscious rabbits[1]. |
| In vivo | In vivo, SAR407899 dose-dependently induced rabbit penile erection, with greater potency and longer duration of action than sildenafil[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 6 mg/mL (24.56 mM), Sonication is recommended.
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| Keywords | SAR-407899 | SAR407899 | SAR 407899 | ROK | ROCK | Rho-kinase | Rho-associated protein kinase | Rho-associated kinase | Rho | Inhibitor | inhibit |
| Inhibitors Related | ITX3 | Fasudil | CCG-257081 | SKLB-163 | Azathioprine | RKI-1447 | Fasudil hydrochloride | Y-27632 dihydrochloride | Tofacitinib | ROCK-IN-5 | Y-27632 | Thiazovivin |
| Related Compound Libraries | Reprogramming Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | TGF-beta/Smad Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Suppliers |
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Sichuan Zhuoyu Yantang Technology Co., Ltd.
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2025-08-14 |
United States