SAR7334 NEW
| Price | $65 | $163 | $263 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2025-05-07 |
Product Details
| Product Name: SAR7334 | CAS No.: 1333210-07-3 |
| Purity: 99.71% | Supply Ability: 10g |
| Release date: 2025/05/07 |
Product Introduction
Bioactivity
| Name | SAR7334 |
| Description | SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM). |
| In vitro | SAR7334 is an inhibitor of TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226 nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents (IC50 of 7.9 nM). SAR7334 (100 nM) substantially reduces TRPC6 currents[3]. |
| In vivo | In isolated perfused lungs from mice, SAR7334 (10mg/kg, p.o.) inhibits TRPC6-dependent acute HPV . SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 350 mg/mL (951.42 mM), Sonication is recommended. |
| Keywords | TRPVChannel | TRPV Channel | TRPChannel | TRPC6 currents | TRPC6 | TRP Channel | Transient receptor potential channels | SAR-7334 | SAR7334 | SAR 7334 | Inhibitor | inhibit |
| Inhibitors Related | (+)-Camphor | Fingolimod hydrochloride | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Capsaicin | trans-Cinnamaldehyde | Methyl salicylate |
| Related Compound Libraries | Membrane Protein-targeted Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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