SB273005 NEW
| Price | $67 |
| Package | 1mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: SB273005 | CAS No.: 205678-31-5 |
| Purity: 99.58% | Supply Ability: 10g |
| Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | SB273005 |
| Description | SB273005 is an orally active and potent nonpeptide integrin αvβ3 antagonist that inhibits αvβ3 and αvβ5 and reduces the production of Th2 cells and the cytokine IL-10 in pregnant mice. |
| In vitro | In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. [1] In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). [3] |
| In vivo | In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. [1] In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. [2] SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. [4] In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : <1 mg/mL Ethanol : 10 mg/mL (22.15 mM), Sonication is recommended. DMSO : 83 mg/mL (183.86 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.31 mM), Sonication is recommended. |
| Keywords | αVβ5 integrin | αVβ3 integrin | SB-273005 | SB273005 | SB 273005 | Integrin |
| Inhibitors Related | Kaolin | Fluorene | Undecane | Ethyl palmitate | Rhamnose monohydrate | Isostearic acid | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose | 1,8-Cineole | Tributyrin | Gluconate Calcium | Magnesium sulfate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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