SBI-477 NEW
| Price | $155 | $397 | $589 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: SBI-477 | CAS No.: 781628-99-7 |
| Purity: 99.30% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | SBI-477 |
| Description | SBI-477 is a chemical probe that stimulates insulin signaling by deactivating the transcription factor MondoA. It coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. |
| In vivo | SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes.??SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4).?Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.14 mM), Sonication is recommended. DMSO : 45 mg/mL (93.06 mM), Sonication is recommended. |
| Keywords | SBI-477 | SBI477 | SBI 477 | MondoA | Inhibitor | inhibit |
| Inhibitors Related | Insulin (human) | Indirubin Derivative E804 | Semaglutide | Morin | Ornithine-α-ketoglutarate | (2S,3R,4S)-4-Hydroxyisoleucine | Picropodophyllin | Sorbic acid | Brigatinib | L-Cysteine hydrochloride hydrate | Tranexamic acid | Linsitinib |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Tyrosine Kinase Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Lipid Metabolism Compound Library | PPI Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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