SCH 42495 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: SCH 42495 | CAS No.: 136511-43-8 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | SCH 42495 |
| Description | SCH 42495 is an orally active neutral metalloendopeptidase inhibitor and serves as the ethyl ester prodrug of SCH 42354. |
| In vitro | SCH 42354 inhibits the hydrolysis of leu-enkephalin and ANF (IC50: 8.3 and 10.0 nM, respectively) [1]. |
| In vivo | SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively. SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a significant reduction in pulmonary vascular remodeling and ventricular hypertrophy in hypoxic rats after 10 days. Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) resulting in a decrease in cardiovascular remodeling secondary to chronic hypoxia in rats [1][2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SCH-42495 | SCH42495 | SCH 42495 | NEP |
| Inhibitors Related | LHW090-A7 | Sacubitril/Valsartan | Sacubitril sodium | Candoxatril | Racecadotril | Sacubitril | NEP-IN-1 | Phenylalanylalanine | Sacubitril hemicalcium salt | Thiorphan | Sacubitrilat | Ilepatril TFA |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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