Seco-DUBA NEW
| Price | $977 | $2190 | $3190 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Seco-DUBA | CAS No.: 1227961-59-2 |
| Purity: 99.81% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Seco-DUBA |
| Description | Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo. |
| In vitro | Method: SK-BR-3 cells were exposed to various concentrations of Seco-DUBA (ranging from 0.0001 pM to 0.01 nM) for 144 hours to evaluate its cytotoxic effects. Result: Seco-DUBA treatment led to a dose-dependent reduction in SK-BR-3 cell viability.[1] |
| In vivo | Method: Pharmacokinetic analysis was conducted in Wistar rats. Seco-DUBA was administered via intravenous injection at a dose of 89 μg/kg. Result: Seco-DUBA was likely converted to DUBA almost instantaneously in vivo. [1] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (151.81 mM), Sonication is recommended. |
| Keywords | Seco-DUBA | Seco DUBA | ADCCytotoxin | ADC Cytotoxin |
| Inhibitors Related | Methotrexate | Doxorubicin hydrochloride | Streptozotocin | Busulfan | Methotrexate disodium | Camptothecin | Dexamethasone acetate | SN-38 | Dexamethasone | Methyl methanesulfonate | Paclitaxel | Exatecan Mesylate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $295.00 |
VIP6Y
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TargetMol Chemicals Inc.
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2026-05-11 | |
|
Sichuan Zhuoyu Yantang Technology Co., Ltd.
|
2025-09-23 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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